General guidelines
Please always check the general deduplication appliances section as the best practices listed there also apply to Dell Data Domain.
Encryption at-rest
Do not enable encryption for the jobs targeted at the deduplication storage appliance as this has a negative effect on the deduplication ratio.
Instead, enable encryption at-rest on the Dell Data Domain. Be aware that this does not protect from data exfiltration, but only protects the data in case the physical device is stolen.
Advanced Scalability
Since v12 you can configure multiple gateway servers to Data Domain in what is known as a Gateway pool. The workloads will be spread across the gateways in the pool to balance the load.
You can also adjust what gateway servers are used for a Data Domain repository by modifying the Gateway selection in the Data Domain repository properties.
References
- KB1745 - Deduplication Appliance Best Practices
- Veeam Alliance Partner Integrations & Qualifications - Dell -> Deduplication Target
- Veeam Help Center - Dell Data Domain
- Veeam Help Center - Backup Infrastructure for Unstructured Data Backup
- Veeam Help Center - Scale-Out Repository with Extents in Metadata and Data Roles